TABLE 1.

AGMs immunized with b/h PIV3/RSV F2 or b/h PIV3/sol RSV F2 were effectively protected from challenge with RSV A2

Immunizing virusaNo. of animalsMean peak titer (log10 PFU/ml) ± SEb
PrechallengePostchallenge
NPBALNPBAL
RSV A233.3 ± 1.55.0 ± 0.4<1.2 ± 0.2<1.0 ± 0.0
b/h PIV3/RSV F245.6 ± 1.0*7.0 ± 0.4*<1.2 ± 0.4<1.2 ± 0.3
b/h PIV3/sol RSV F245.6 ± 0.2*6.8 ± 0.4*<1.1 ± 0.2<1.0 ± 0.0
hMPV3NDND4.0 ± 0.15.0 ± 0.2
Placebo20.0 ± 0.00.0 ± 0.04.3 ± 0.35.7 ± 0.3
  • a Animals were inoculated with the indicated virus at each site intranasally and intratracheally in a 1-ml volume.

  • b Mean peak virus titer is the mean of the highest titer of virus of each animal in the specific group during the course of the study. Animals were challenged on day 28 with 7 × 105 PFU of RSV A2. ND, not determined. *, P = 0.0571 (two-sided Wilcoxon exact P values) for NP and BAL compared to RSV A2. P = 1.0 (NP) and P = 0.486 (BAL) compared to each other.