TABLE 1.

Proportions of cholesterol to sterol analogue in lipid-modified HIV-1a

Treatment groupConcn (μg/mg of p24) of:Sterol levels vs control (%)Cholesterol: cholesterol analogueNo. individual exptsMean buoyant density (g/ml)
CholesterolCholesterol analogueTotal sterol
Control2.14 (0.17)NA2.14 (0.17)100NA41.149 (0.001)
CD (0.5 mM)1.23 (0.22)NA1.23 (0.22)57NA41.157 (0.001)
CD + replenishment with:
    Cholesterol3.45 (0.45)NA3.45 (0.45)161NA41.145 (0.004)
    Epicholesterol1.49 (0.15)1.00 (0.20)2.49 (0.34)11660:4031.149 (0.001)
    4-Cholestenone0.91 (0.40)1.54 (0.89)2.45 (0.52)11537:6331.149 (0.001)
    7-Dehydrocholesterol0.99 (0.28)1.13 (0.13)2.12 (0.37)9947:5331.149 (0.001)
    Dihydrocholesterol1.18 (0.14)1.22 (0.34)2.40 (0.45)11249:5141.151 (0.005)
    Coprostanol1.91 (0.33)1.29 (0.28)3.20 (0.37)15060:4041.151 (0.004)
  • a Standard deviations of the means are given in parentheses. NA, not applicable.