TABLE 1.

Humoral and cellular immune responses in vaccinated baboons at wk 38a

GroupGeometric mean (range) of antibody titerMean SFU (range) by ELISpotMean % (range) of IFN-γ+CD8+ cells by ICS with OLP:
ProteinOLP
Anti-CAnti-ECECE1E2CE1E2(1)bE2(2)c
HCV-LP1,072 (400-3,200)3,200 (400-6,400)26 (11-37)17 (9-27)29 (22-34)28 (14-49)42 (16-98)0.018 (0-0.042)0.062 (0-0.128)0.047 (0-0.188)0.031 (0-0.071)
HCV-LP + AS01B1,902 (800-6,400)4,525 (3,200-6,400)48 (21-81)64 (26-122)54 (30-94)31 (0-51)88 (35-182)0.016 (0-0.028)0.025 (0-0.081)0.024 (0-0.046)0.098 (0-0.039)
HCV-LP + AS01B/CpG1,902 (800-6,400)4,525 (3,200-6,400)36 (21-76)42 (20-101)55 (29-71)52 (31-69)86 (67-115)0.054 (0.013-0.131)0.075 (0-0.121)0.041 (0.03-0.056)0.05 (0.033-0.07)
vvHCV.S<507034299310000
  • a Anti-C, anti-HCV core antibody; anti-E, anti-HCV E1 and/or E2 antibody.

  • b E2 overlapping peptides spanning the N-terminal E2.

  • c E2 overlapping peptides spanning the C-terminal E2.