TABLE 1.

Average enhancement in infectivity and average increase in reverse transcription of virions caused by three drugs

VirusFold infectivity enhancementaFold reverse transcription enhancementb
CytDLatBJasCytDLatBJas
LAI1.97 ± 0.21 (16)1.24 ± 0.16 (14)1.29 ± 0.32 (4)4.18 ± 0.81 (5)2.33 ± 0.45 (5)1.25 ± 0.30 (3)
LAIΔNef7.48 ± 0.93 (16)5.18 ± 0.72 (14)9.47 ± 2.36 (4)11.72 ± 1.22 (5)5.60 ± 0.98 (5)7.34 ± 1.46 (3)
LAI VSV0.93 ± 0.30 (3)0.71 ± 0.13 (3)0.585 ± 0.14 (4)NDNDND
LAIΔNef VSV1.42 ± 0.34 (3)1.59 ± 0.37 (3)0.878 ± 0.21 (4)NDNDND
  • a Average fold enhancement observed in the presence of the indicated drug relative to control infection. The number of infections (n) is shown in parentheses and is similar to the infections shown in Fig. 1A and C. Data are means ± standard errors of the means obtained from averaging n experiments.

  • b Average increase in late reverse transcription products per cell calculated in the presence of the indicated drug relative to control infection. The number of infections (n) is shown in parentheses and is similar to the infections shown in Fig. 3A and C. Data are means ± standard errors of the means obtained from averaging n experiments. ND, not determined.