TABLE 7.

Virus replication in β2-m−/− mice infected with a low dose (103 PFU) of WNVa

Days p.i.SerumBrainLiverSpleen
1<102<103<103<103
<102<103<103<103
<102<103<103<103
2<1021.0 × 103<103<103
<102<103<103<103
<102<103<103<103
3<102<103<103<103
<102<103<103<103
<102<103<103<103
4<102<103<103<103
<1024.8 × 103<103<103
5.0 × 1046.6 × 1037.2 × 1032.0 × 103
5<1028.3 × 1061.5 × 1032.0 × 103
<1026.2 × 1042.3 × 1041.5 × 103
<1029.2 × 103<103<103
6<1024.8 × 106<103<103
<1023.5 × 104<103<103
<1026.9 × 106<103<103
7<1021.6 × 1061.0 × 103<103
<1026.3 × 109<103<103
<1023.6 × 1054.0 × 1041.0 × 103
9<1025.0 × 108<103<103
<1026.0 × 109b<103<103
<1022.2 × 105<103<103
11<1024.9 × 109b<103<103
<1023.2 × 109b<103<103
<1025.6 × 106<103<103
13<1028.4 × 108<103<103
<1029.2 × 109b<103<103
<1027.7 × 107<103<103
15<1022.1 × 109b<103<103
<1024.6 × 108<103<103
<1027.5 × 109b<103<103
  • a Units for values are as described in Table 2, footnote a. The limit of detection is 102 PFU/ml for serum or 103 PFU/g for tissue. Mice were randomly selected from a pool of experimental mice early after infection. Table contains data from four independent experiments.

  • b Values for moribund mice, which were used at later time points.