TABLE 6.

Virus replication in β2-m−/− mice infected with a high dose (108 PFU) of WNVa

Days p.i.SerumBrainLiverSpleen
1<1024.0 × 104<103<103
<1027.3 × 103<103<103
<1022.0 × 104<103<103
2<1021.5 × 106<103<103
<1022.0 × 105<103<103
<1023.0 × 106<103<103
3<1027.0 × 103<103<103
<1025.1 × 109<103<103
5.0× 1036.6 × 1066.0× 104<103
4<1021.6 × 108<103<103
<1026.2 × 107<103<103
<1025.8 × 108<103<103
5<1023.4 × 109b<103<103
7.2× 1044.4 × 107<103<103
<1026.5 × 1085.0× 1031.0 × 103
6<1024.9 × 106<103<103
<1027.2 × 109<103<103
<1021.0 × 109b4.0× 1032.0 × 103
7<1025.0 × 107<103<103
<1022.0 × 108b4.0× 1056.1 × 103
<1026.4 × 109b<103<103
9<1023.7 × 109<103<103
<1022.6 × 109b4.0× 1042.5 × 104
<1021.5 × 109b5.0× 1032.5 × 103
11<1029.3 × 106<103<103
<1024.8 × 106<103<103
<1022.9 × 109b<103<103
13<1027.0 × 109b<103<103
<1023.6 × 108<103<103
<1021.7 × 109b<103<103
  • a Units for values are as described in Table 2, footnote a. The limit of detection was 102 PFU/ml for serum or 103 PFU/g for tissue. Mice were randomly selected from a pool of experimental mice early after infection. Table contains data from four independent experiments.

  • b Values for moribund mice, which were used at later time points.