TABLE 4.

Percentage of activated CD8+ T cells in spleen and brain cells after infection of mice with 103 PFU of WNVa

Days p.i.% CD8+ T cells expressing activation markers (SD)
SpleenBrain
CD69CD25CD69CD25
0 (Control)1.6 (1.1)1.5 (1.0)NDbND
15.7 (1.1)c1.7 (0.5)28.8 (7.7)1.6 (1.2)
24.7 (2.2)c1.4 (0.4)31.1 (5.3)1.0 (0.6)
32.3 (0.5)1.8 (0.4)6.3 (3.3)d1.6 (0.8)
42.4 (0.6)6.7 (0.8)c3.7 (1.6)d4.5 (5.0)
52.5 (1.3)3.8 (3.0)c3.9 (1.9)d6.2 (7.7)
72.0 (1.1)4.2 (1.4)c3.6 (2.8)d9.6 (5.2)e
91.8 (0.9)3.4 (0.9)c0.8 (0.5)d9.7 (3.6)e
111.5 (0.8)2.8 (1.5)0.9 (0.8)d10.9 (9.2)e
121.7 (1.2)3.1 (1.7)c0.8 (1.1)d9.8 (9.2)e
  • a B6 mice were injected i.v. with 103 PFU of WNV (n= 5).

  • b ND, not detectable.

  • c P < 0.05 compared with mock-treated mice (control).

  • d P < 0.05 compared with days 1 and 2.

  • e P< 0.05 compared with days 1, 2, and 3.