TABLE 1.

Concentration resulting in 50% inhibition of HCVcc entry

Virus50% neutralization concna (μg/ml) of:
Antibodies from sera positive for indicated HCV genotypeMAb 3/11Lectin CV-NbCD81-LEL
1a1b24
Wild type3.9 (1.0)>10 (1.0)10 (1.0)>10 (1.0)>10 (1.0)0.3 (1.0)4.3 (1.0)
HCVcc mutant
    E2N11.4 (2.8)1.3 (>7.7)1.3 (7.7)0.7 (>14.3)0.4 (>25.0)0.2 (1.5)0.6 (7.2)
    E2N20.6 (6.5)0.7 (>14.3)0.7 (14.3)0.5 (>20.0)0.4 (>25.0)0.4 (0.8)0.5 (8.6)
    E2N40.7 (5.6)0.7 (>14.3)0.7 (14.3)0.6 (>16.7)0.6 (>16.7)0.3 (1.0)0.6 (7.2)
    E2N5>10 (<0.4)>10 (ND)>10 (<1.0)>10 (ND)>10 (ND)0.5 (0.6)>10 (<0.4)
    E2N60.6 (6.5)0.6 (>16.7)0.7 (14.3)0.5 (>20.0)2.8 (>3.6)0.4 (0.8)0.5 (8.6)
    E2N94.3 (0.9)2.9 (>3.4)8.1 (1.2)2.2 (>4.5)>10 (ND)0.5 (0.6)>10 (<0.4)
    E2N111.5 (2.6)1.0 (>10.0)1.6 (6.3)0.8 (>12.5)2.4 (>4.2)0.5 (0.6)2.5 (1.7)
  • a Values in parentheses are differences (n-fold) from the 50% neutralization concentration of the wild-type. ND, not determined.

  • b CV-N, cyanovirin-N.