TABLE 1.

CD4+ T-cell epitope mapping in four controllers with the HLA-DRB1*13 and/or HLA-DQB1*06 allele

Subject no. (tissuea)Class II HLA allele(s)CD4+ IFN-γ response (SFC/million) to peptide:
Gag p24 (aa 165-179)Gag p24 (aa 251-265)Gag p24 (aa 295-309)Gag p1 (aa 429-447)Nef (aa 61-75)Nef (aa 81-95)
1116 (PB)DRB1*13/DQB1*062151721,30000195
1198 (RM)DQB1*067004007341150
1517 (RM)DQB1*06150019280400
1518 (PB/RM)DQB1*060070/95164068
  • a PB, peripheral blood; RM, rectal mucosa.