TABLE 3.

Virus mutation rates expressed as substitutions per nucleotide per strand copying (μs/n/r)a

GroupVirusμs/n/rTsReference(s)
ssRNA(+)PV-18.9 × 10−6182
ssRNA(−)VSV6.0 × 10−6636
FLUVA9.0 × 10−62-585, 86
Measles virus (MV)b4.4 × 10−5∼7.581
dsRNAφ61.4 × 10−6∼5.69
ssDNAφX174c2.1 × 10−7∼6.419
1.0 × 10−6712
dsDNAλ7.9 × 10−83825, 26
T22.0 × 10−81,57626, 55
  • a All estimates were obtained using the fluctuation test, except for λ, where the rate per cycle of copying was calculated assuming binary replication (26).

  • b Genome size, 15.9 kb.

  • c Geometric mean, 4.6 × 10−7.