TABLE 3.

TZMbl neutralization data

Patient no.Antibody no.ClusteraNeutralizing activity (IC50 [μg/ml])b
TRO.11RHPA4259.7
111IV>500>500
27I-ID433>500
96II, IV>500>500
167II>500>500
491II>500>500
696I-ID651>500
763II, IV>500>500
255I>1,030>1,030
149I-ID>1,030*>1,030
150II>1,500>1,500
275II>1,500>1,500
378I-ID>1,560>1,560
474II, IV>1,500>1,500
512IV1,276>1,500
1007I-ID>1,000>1,000
1290II, IV>1,500>1,500
318II, IV>1,500>1,500
64IV>1,500>1,500
125II>1,500>1,500
140II, IV>1,500>1,500
160IV>1,500>1,500
204II, IV>1,500>1,500
233IV>1,500>1,500
255IV>1,500>1,500
296II, IV>1,500>1,500
334IV>1,500>1,500
384II>1,500>1,500
461II, IV>1,500>1,500
474II>1,500>1,500
650II, IV>1,500>1,500
420I-ID508>1,100
63IV>1,500>1,500
95I-ID, IV>670>670
104I, IV1,712>2,380
147VI, II>1,500>1,500
153I-ID, IV>1,500>1,500
157I>1,500>1,500
251I8411,234
283II>1,360>1,360
342II>1,500>1,500
357I, IV>665>665
380II, IV>1,500>1,500
431I-ID>690>690
613II, IV>1,500>1,500
525I964>1,050
691IV>1,500>1,500
129II>1,500>1,500
  • a ID, binds to the immunodominant peptide.

  • b Both TRO.11 and RHPA4259.7 are tier 2, clade B viruses. Values in boldface represent the concentration at which the tested monoclonal antibodies showed 50% neutralization. *, values that almost reached the IC50 at the highest antibody concentration tested.