TABLE 1.

Summary of Rep constructs and their activities

Rep proteinDNA bindingEndonuclease on:ATPase/helicaseC-terminal domainReplication of AAVInhibition of HSV-1ApoptosisDNA damage
ssDNAdsDNA
Rep52++
Rep68++++++++
Rep78+++++++++
Rep78(Y156F)++++++
Rep78(K340H)++++/−