TABLE 3.

Neutralization IC50s for various 4E10 constructs against four HIV-1 clade B isolates

4E10 constructNeutralization IC50 (SE) [relative IC50]a (μM) against HIV isolate:
SF162SS1196HxB2JRFL
IgG4E10wt0.012 (4) [0.09]0.002 (1) [0.03]0.005 (1) [0.2]0.008 (4) [0.3]
IgG4E10[G(L50)E]0.009 (6) [0.07]0.0015 (7) [0.02]0.003 (2) [0.1]0.004 (2) [0.1]
Fab4E10wt0.062 (7) [0.5]0.046 (9) [0.7]0.007 (4) [0.3]0.009* [0.3]
Fv4E10wt0.13 (2) [1]0.07(1) [1]0.026(7) [1]0.029 (3) [1]
Fv4E10[W(H100)A]>0.8 [>6]0.22 (2) [3]0.09 (2) [3]0.072 (5) [2]
Fv4E10[G(L50)E]0.1 (2) [0.8]0.02 (1) [0.3]0.013 (9) [0.5]0.0103 (8) [0.4]
  • a Relative IC50s, referenced to Fv4E10wt, are calculated in each column separately for each isolate and are shown in brackets. *, performed only in duplicate, and so no error estimate was calculated.