TABLE 1.

Kd values obtained for interactions between MA and all PIP species in the presence or absence of PSa

PIP speciesMean Kd ± SDFold change
No PSbIn the presence of PSc
PI(3)P42.1 ± 13.743.3 ± 8.51.0
PI(4)P25.3 ± 0.520.9 ± 3.21.2d
PI(5)P47.4 ± 5.432.8 ± 7.81.4d
PI(3,4)P215.1 ± 0.930.0 ± 5.12e
PI(3,5)P224.9 ± 6.736.0 ± 3.81.4e
PI(4,5)P221.7 ± 1.35.4 ± 1.74.0d
PI(3,4,5)P315.6 ± 1.6NA
  • a Also given is the variation in Kd with the PS addition, either a decrease (i.e., enhanced affinity) or increase (i.e., lower affinity). NA, not applicable.

  • b PC/PIP ratio of 95:5.

  • c PC/PS/PIP ratio of 75:20:5.

  • d Decrease.

  • e Increase.