TABLE 1.

LD50 values of wild-type HSV-2, YK356, and YK361

VirusLD50 (PFU)a
IntracerebralIntraperitoneal
HSV-2 1862.2146
YK3563.268
YK3613.2100
  • a Three-week-old female ICR mice were inoculated intracerebrally or intraperitoneally, as indicated, with serial 10-fold dilutions of each virus in groups of six per dilution and monitored for 21 days. The LD50 values were determined by the Behrens-Karber method.