LD50 values of wild-type HSV-1, HSV-2, and recombinant viruses in mice after intracerebral inoculation

VirusLD50 (PFU)a
YK511 (Us3K220 M)68,000
YK513 (Us3-KM-repair)100
HSV-2 1860.46
YK811 (Us3K220 M)10
YK813 (Us3-KM-repair)1.46
  • a Three-week-old female ICR mice were inoculated with serial 10-fold dilutions of each virus in groups of six per dilution and monitored for 21 days. The LD50 values were determined by the Behrens-Karber method.