TABLE 1.

Summary of phenotypic and functional analysis of GLC- versus TLD-specific CD8+ T cellsa

Sample (no. of mo) and T-cell epitope% Tetramer-positive cells with indicated phenotype/markerMFI ratio for PD-1b
CCR7+ CD45RACCR7 CD45RACCR7 CD44RA+CD38Ki67Bcl2IL-7RαCD107αIFN-γTNF-αMIP-1βIL-2
IM140.1
    GLC0.488.410.998.874.14.55.8NTNTNTNTNT17.5
    TLD1.573.224.610050.09.55.887.951.151.27.811.511.5
IM140.3 (8)
    GLC1.337.259.712.55.852.412.057.831.527.98.29.56.9
    TLD1.919.576.519.56.152.836.071.714.826.47.06.03.9
IM140.4 (10)
    GLC1.726.270.940.57.554.3 24.0 64.231.924.78.810.0 4.5
    TLD3.214.380.857.99.050.8 64.0 73.214.922.77.76.9 103.5
IM119.2 (4)
    GLC4.673.720.171.411.146.7 11.6 50.052.161.717.04.9 7.4
    TLD1.475.921.358.810.551.5 41.6 59.411.828.38.612.3 88.2
IM123.2 (2)
    GLC1.580.56.592.58.631.2 18.0 48.725.226.410.712.5 20.3
    TLD4.874.720.584.610.736.1 48.0 52.814.817.45.57.7 68.9
  • a Numbers refer to the percentages of tetramer-positive cells with the relevant phenotype or (following peptide stimulation) functional markers. NT, not tested. Underlined values identify key differences between GLC- and TLD-specific cell phenotypes.

  • b Data for PD-1 staining of tetramer-positive cells are expressed as MFI ratios.