TABLE 6.

Neutralization of HIV-1JR2 mutantsa

Mutationgp41 sequenceIC50 (μg/ml)
Z13e14E10
Wild typeL W N W F D I S N W L W Y I K71.28.6
Ser676→ThrL W N W F D I T N W L W Y I K69.57.5
Asn671→SerL W S W F D I S N W L W Y I K61.55.6
Asn671→AspL W D W F D I S N W L W Y I K55.45.4
Asn671→ThrL W T W F D I S N W L W Y I K>200b10.0
Phe673→LeuL W N W L D I S N W L W Y I K38.6>100b
Asp674→GluL W N W F E I S N W L W Y I K91.915.0
  • a Mutated residues are shown in boldface type. IC50, 50% inhibitory concentration.

  • b Neutralization was not observed at the highest concentration tested (200 μg/ml for Z13e1 and 100 μg/ml for 4E10).