TABLE 1.

Summary of the values obtained in this study

Cell typeMean time (h) ± SDaΔRT-IN
tRT50%tIN50%tStab50%tUncoat50%b
HeLa3.7 ± 1.2C16.3 ± 1.8D3.8 ± 1.2ND12.6
PBLs (24 h)16.5 ± 1.4A25.1 ± 3.2B16.2 ± 3.312 ± 2.88.6
PBLs (12 h)26 ± 2.833 ± 1.924.6 ± 1.115.5 ± 4.67
PBLs (72 h)10.5 ± 2.717.6 ± 1.95.16 ± 3.26.5 ± 1.47.1
Macrophages24.2 ± 7.726.7 ± 5.816.6 ± 1.424.7 ± 62.5
PBLs (nocodazole)25 ± 532 ± 2.5NDND7
HeLa (nocodazole)4.6 ± 0.215.2 ± 0.2NDND10.6
HeLa (X4)5.6 ± 2.3C17.5 ± 0.5D3.5 ± 0.5ND11.9
PBLs (X4)15 ± 0.4A27.3 ± 4.49B12.6 ± 415 ± 0.712.3
  • a Identical superscript capital letters indicate paired conditions that display a P of >0.05 (Student t test). ND, not determined.

  • b t50%, the mid values between those obtained at t0 and the 100% value obtained at t48. Uncoating is measured here based on the susceptibility to Cs.