TABLE 1.

Summary of results for mice inoculated with influenza A viruses by the ocular route

VirusName in this studySubtypeIVPIaVirulence following intranasal inoculationbIntraocular inoculation resultc
No. of mice with virus in eye/totalExtraocular virus detectionVirulence
Day 3 p.i.Day 6 p.i.
A/Netherlands/219/03NL/219H7N7HPAIHigh3/63/6YesHigh
A/Netherlands/230/03NL/230H7N7HPAILow4/64/6YesLow
A/Ck/Netherlands/1/03Ck/NL/1H7N7HPAILow0/32/3YesLow
A/Canada/504/04Can/504H7N3HPAILow6/63/4YesLow
A/Canada/444/04Can/444H7N3LPAILow4/66/6YesLow
A/New York/107/03NY/107H7N2LPAILow0/30/3NoLow
A/Hong Kong/483/97HK/483H5N1HPAIHigh3/62/6YesHigh
A/Thailand/16/04Thai/16H5N1HPAIHigh0/31/6YesHigh
A/Vietnam/1203/04VN/1203H5N1HPAIHigh0/50/5YesLow
A/Aichi/1/68Aichi/68H3N2NALow0/30/3YesLow
A/Memphis/102/72Mem/72H3N2NALow0/30/3NoLow
A/South Carolina/1/18SC18H1N1NAHigh0/30/3YesLow
A/South Carolina/1/18dAV18H1N1NAHigh0/30/3YesLow
  • a IVPI, intravenous pathogenicity index; NA, not applicable.

  • b As described previously (4, 19, 24, 25, 42).

  • c Following 106 EID50 or PFU/5-μl ocular inoculation following corneal scarification.

  • d SC18 virus possessing altered α2-3 SA binding specificity as described previously (45).