TABLE 1.

Levels of surface receptor expressiona

CellsCARαvβ3αvβ5αvβ6
% PositiveGeometric mean fluorescence% PositiveGeometric mean fluorescence% PositiveGeometric mean fluorescence% PositiveGeometric mean fluorescence
BT205.0114.791.050.1093.0015.0196.3533.08
DX3-β69.0712.7497.3821.9288.9717.6996.55156.56
TR1263.9646.521.631.361.564.0094.8272.28
SKOV3ip156.9137.306.4511.1132.7229.1550.1117.09
TR13856.3971.17NDNDNDND94.16115.86
SCC2596.5537.2262.0820.549.914.1597.4272.19
  • a Geometric mean fluorescence and percent positive statistics were collected using single-parameter histograms (FL1-H). Negative control isotype IgG fluorescence values were subtracted from the geometric mean fluorescence of the test antibody (mouse IgG1, anti-CAR [RmcB], anti-αvβ3 [LM609], and anti-αvβ5 [P1F6]; rat IgG2a, anti-αvβ6 [53A.2]). ND, not determined.