TABLE 3.

Logistic survival for estimating the effects of cellular and humoral immunity at the time of PML diagnosis on 1-year survivala

ParameterAll PML patientsPatients with laboratory-confirmed or definitive diagnosis
Odds ratio (95% CI)POdds ratio (95% CI)P
JCV-specific cellular immune response (estimates by 10-fold higher of parameter +1)
    Unadjusted0.36 (0.09, 1.20)0.100.06 (0.00, 0.62)0.02
    Adjusted for CD4 cell count0.45 (0.11, 1.57)0.210.11 (0.00, 1.56)0.11
CMV-specific cellular immune response (estimates by 10-fold higher of parameter +1)
    Unadjusted1.00 (0.46, 2.19)1.000.67 (0.12, 2.00)0.49
    Adjusted for CD4 cell count1.23 (0.53, 3.04)0.631.15 (0.13, 19.97)0.88
JCV VLP IgG response (estimates by 2-fold-higher parameter value)
    Unadjusted0.51 (0.27, 0.84)0.0070.62 (0.30, 1.08)0.09
    Adjusted for CD4 cell count0.54 (0.28, 0.90)0.020.67 (0.28, 1.31)0.24
JCV VLP IgM response (estimates by 2-fold-higher parameter value)
    Unadjusted0.84 (0.34, 1.49)0.580.46 (0.12, 1.39)0.17
    Adjusted for CD4 cell count0.88 (0.36, 1.57)0.680.29 (0.00, 1.30)0.12
  • a Univariate analyses and analyses adjusted for CD4 cell counts based on logistic regression using Firth's bias reduction. CI, confidence interval.