TABLE 3.

HAI titers against A/PR8/34 from a single immunizationa

Vaccine group (μg)bWk 2 after primingDay 4 after challenge
HAI titers (±SD)Log2 (±SD)HAI titers (±SD) (fold increase)Log2 (±SD)
HA (0.5)+mLT24 ± 24.6 ± 1100 ± 2 (4.2)6.6 ± 1
HA (0.5)24 ± 24.6 ± 172 ± 2 (3)6.2 ± 1.5
HA (0.1)+mLT24 ± 1.54.6 ± 0.648 ± 2 (2)5.6 ± 1
HA (0.1)18 ± 24.2 ± 136 ± 3 (2)5.2 ± 1
HA 0.02)+mLT18 ± 24.2 ± 140 ± 4 (2.2)5.3 ± 1
HA (0.02)12 ± 1.53.6 ± 0.618 ± 2 (1.5)4.2 ± 1
HA (0.5)+CTB24 ± 24.6 ± 196 ± 2 (4)6.6 ± 1
Naïve12 ± 14.2 ± 0
  • a HAI titers against A/PR8/34 virus at week 2 after a single immunization or at day 4 after challenge infection. Data are from three different experiments.

  • b Groups of mice are as described in the legend of Fig. 1. mLT, mutant LT(R192G).