TABLE 1.

Baseline characteristics for 29 PML cases

CharacteristicsaSummary statisticbPc
All patients (n = 29)Survivors (n = 18)Nonsurvivors (n = 11)
Age (yr)39 (36, 45)37 (34, 44)42 (39, 45)0.13
Female gender5 (17)2 (11)3 (27)0.34
PML diagnosis
    Definitive4 (14)2 (11)2 (18)0.09
    Laboratory confirmed10 (34)4 (22)6 (55)
    Possible15 (52)12 (67)3 (27)
Yr since first positive HIV test8.20 (2.72, 11.34)7.10 (0.51, 9.14)10.81 (8.30,13.19)0.03
CD4 cell count (cells/μl)102 (35, 152)119 (82, 192)35 (18, 107)0.02
CD8 cell count (cells/μl)700 (455, 1137)698 (546, 1030)700 (425, 1168)0.74
HIV viral load (log10 copies/ml)4.18 (2.62, 5.28)3.88 (2.62, 4.88)4.98 (2.79, 5.41)0.22
Prior AIDS-defining conditions12 (41)9 (50)3 (27)0.27
cART status at PML diagnosis
    cART naïve10 (34)7 (39)3 (27)0.45
    cART treated10 (34)7 (39)3 (27)
    cART interrupted9 (31)4 (22)5 (45)
cART (re)initiated within 3 mo of PML diagnosis
    In cART-naïve patients7/10 (70)6/7 (86)1/3 (33)0.10
    In cART-pretreated patients4/9 (44)3/4 (75)1/5 (20)
  • a Time-dependent covariates evaluated at the time of PML diagnosis.

  • b Median (IQR) for continuous variables; n (%) for categorical variables.

  • c Survivors versus nonsurvivors; based on Wilcoxon test for continuous variables and Fisher's exact test for categorical variables.