TABLE 3.

CTL mutations in protease

Codon in PRConsensus B residueResidue in virus from patienta:
302430623021304130363077303730881001b10021003b10041005b1006
M0M21M38M7M16M31M9M30M59M3M18M32M6M13M22M5M22M37M8M16M38M6M18M23D0D138D0D287D0D110D0D489D0D1253D0D220
10LIL/I
12TEEESSS/PAA, T
13IVVVI/VI/VVV
15IVVV/IVVVA/N/IA/V/IV/I
16GEEE
19LII/KI/KIIII/TII
20KK/RK/R
34EDE/D
35EDDD/ED/ED/ED/EDDDNN/T
36MII/TI/LLLLSSSI/TI/T/VI/MM/IM/III/V
37NHH/QH/PS/N/DS/NS/N/DS/N/AS/N/T/HS/N/A/QSS/NSEEES/N/HS/N/H/TS/NDDSSSS
39PP/LP/LPSSS
41RR/K/GR/KKKKKKKKR/KKKKKKK
45KRRR/K
46MIM/I
57RKKKKKKK/RK/R
62IVVVVVVVI/VVV
63LPPPPPPP/HP/H/TP/HPPPQQQPPPPPPQQQ/PPPPPPPP/LPPP
64II/LVVVVM/V
69HNNN
70KRRRTT,/A
71ATT
72II/EI/E
77VIM/IV/II
82VII
85IVI/V
90L
92QK/RK/RK/RML/M
93ILLLLLLLLLLLL
  • a Residues in bold indicate previously defined CTL escape mutations (5, 25).

  • b Multiple-variant transmission or superinfection.