TABLE 3.

Frequency of substitutions in RT detected by UDPS in the study patients not previously described in literature

RT substitutionTreated patients (n = 8)Naïve patients (n = 5)
naHBV genotypeFrequency (%)naHBV genotypeFrequency (%)
rtE8K1D1.40
rtV27F2A1.70, 4.47
rtV27F3D1.33, 2.39, 4.163D3.35, 4.49, 5.17
rtH35Y1D2.19
rtA38P1D1.481D1.87
rtH53S1D19.04
rtN53K1D2.42
rtH54S1D2.33
rtH54T1D2.47
rtR55H1D2.47
rtA87V1D1.50
rtI91F1D1.611D1.13
rtI91P1D1.13
rtA97T1D1.06
rtG107R2D1.17, 1.861D1.22
rtN118Y1D1.30
rtN118T1D1.38
rtR120S1D8.13
rtI121N1D1.10
rtF122I1D2.35
rtF122N1D3.20
rtF122S1D1.40
rtQ125H1D1.11
rtH126Y1D2.902D3.17, 97.91
rtD131S1D4.10
rtD134G1D1.30
rtD134V2D61.4, 54.8
rtH135T1D82.47
rtC136Y1D1.001D1.02
rtD139K1D2.871D7.55
rtD139Q1D1.101D3.15
rtD139S1D1.09
rtY141Q1D69.90
rtV142E2D10.46, 18.65
rtL145 M1D4.951D1.75
rtK149H1D4.41
rtF151Y1D3.941D1.65
rtH160R1D2.19
rtA186T1D1.16
rtC188R1D1.16
rtR192S1D1.16
rtE218D1D21.9
rtS230P1D2.46
rtI233 M1D2.46
rtI233T1D2.22
rtL235stop1D2.171D1.15
rtP237L1A1.09
rtP237T1D53.082A, D46.78, 99.49
rtA238H2D2.22, 2.51D1.76
rtR242G1D1.231D1.17
rtY245H1D6.60
rtS246P1A1.09
rtH248Y1D1.23
rtF249L1A1.09
rtM250T1D1.23
rtI253T1A5.00
rtY257G1D2.00
rtY257W1D53.081D94.94
rtW257L1A12.00
rtT259P1A12.90
rtH264Y1D1.23
rtI266V2D46.91, 99.13
rtQ267H1D1.142A, D46.78, 97.97
rtI269T1D1.23
rtE271H2D11.1, 99.13
rtH271D1A46.20
rtH271F1A12.90
rtR274S2A; D4.76, 2.22
rtI278A1D1.60
rtV278I1A41.6
rtW284R1A2.40
  • a n, number of patients showing the indicated substitution.