TABLE 2.

Comparison of UDPS, DR v2, and direct sequencing for HBV from eight patients under treatment

PatientPresence or frequency of mutationa
Codon 80Codon 173Codon 180Codon 181Codon 204Codon N236
L80 (wt)L80I/VbV173 (wt)V173LL180 (wt)L180MA181 (wt)A181T/VbM204 (wt)M204I/VbN236 (wt)N236T
UDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DSUDPS %DR v2DS
196YY4<1<1100YY92YY8<1<198YY2<1<195YY5*<1*<1*100YY
2100YY100YY100YY97YY3Y<1100YY78YY22Y<1
373YY24/3*Y/Y*Y/<1*100YY100YY100YY88YY12Y<1100YY
497YY3*Y*<1*100YY100YY100YY100YYN*Y*<1*100YY
598YY2<1<1100YY97YY3<1<193YY7*<1*<1*98YY2*<1*<1*88YY12Y<1
6100YY38YY62YY40YY60YY98YY2*<1*<1*39YY21/40*Y/Y*Y/Y*
782YY18*Y*<1*95YY5Y<123Y<177YY100YY0<1<124/76*Y/Y*Y/Y*100YY
8100YY100YY59YY41YY100YY58YY42*Y*Y*100YY
  • a The table reports all the mutations included in the DR v2. For UDPS, the results include the mutation frequency (UDPS %) in each treated patient. (Note that the frequency values have been adjusted to the nearest integral number.) Y and <1% indicate detected and not detected, respectively. DS, direct sequencing.

  • b Where alternative mutations are found at codons 80 (I or V), 181 (T or V), and 204 (I or M), the correspondence in the columns is indicated by the asterisk.