TABLE 3.

Insertions in various regions of the RTA locus

RegionGenome coordinatesSize (bp)Total (%) insertionsTotal (%) critically impairedNo. (%) attenuatedNo. (%) tolerated
ORF47-48 intergenic65570-65581121 (0.1)1 (100.0)00
ORF4865582-665831,002255 (20.7)80 (31.4)68 (26.6)107 (42.0)
ORF48-49 intergenic66584-6673815551 (4.1)10 (19.6)5 (9.8)36 (70.6)
ORF4966739-67644906319 (26.0)93 (29.1)72 (22.6)154 (48.3)
RTA exon 1a66761-667963611 (0.9)4 (36.4)3 (27.2)4 (36.4)
ORF49-RTA exon2 intergenic67645-67661178 (0.7)01 (12.5)7 (87.5)
RTA exon267662-693771,716584 (47.5)204 (35.0)131 (22.4)249 (42.6)
RTA-gp150 intergenic69378-694143711 (0.9)5 (45.5)5 (45.5)1 (9.0)
RTA locus total65570-694143,8451,229 (100.0)393 (32.0)282 (22.9)554 (45.1)
  • a Since the RTA exon 1 overlaps with ORF49, the exon 1 insertions were not recounted when calculating the RTA locus total insertions.