TABLE 2.

Clinical outcomes for individual monkeys in each group after monkeypox virus challengea

Group and animal no.No. of skin lesion on indicated day postchallengeLesions fusedTemp change% Weight loss (day postchallenge)ND50 on day 9Other CSDay of death
47911142128
Mock
    7337b26519+9.1 (9)4Yes9b
    7329974737781,1241,283++++Decreased6.3 (14)32Yes14
    732725201,195++++No11.2 (9)64Yes9
    7328215871,1381,936++++No8.2 (11)64Yes11
    733432202462603679500272+++No7.1 (7)64YesSurvived
    73364256406559671410140+++No7.1 (9)64YesSurvived
Mean ± SD26 ± 27351 ± 206666 ± 4,5661,056 ± 641878 ± 351455 ± 64206 ± 937.0 (9)
Dryvax
    73320000000NoNo<21,024NoSurvived
    73260000000NoNo<2512NoSurvived
    73300000000NoNo<2512NoSurvived
    73310205200NoNo<2512NoSurvived
    73331000000NoNo<21,024NoSurvived
    73350001200NoNo<2512NoSurvived
Mean ± SD00 ± 101 ± 11 ± 100No
Pc0.1030.0060.0280.0370.0310.0350.048
Cidofovir+Dryvax
    73210113145121124213+No4.3 (4)256YesSurvived
    7325078956997233+No5.2 (4)512NoSurvived
    73200144283424607548342+++No8.3 (9)256NoSurvived
    73224403106213671758++++Decreased11 (11)32Yes14
    732433137203223395307126++No5.5 (11)256NoSurvived
    732310215383422606361240+++No11 (28)128NoSurvived
Mean ± SD8 ± 13182 ± 117362 ± 356438 ± 478598 ± 610252 ± 228143 ± 1496.4 (14)
Pd0.1670.0310.0550.0310.1350.0470.119
  • a CS, clinical signs, including depression, weakness, cough, unresponsiveness, dyspnea, dehydration, and anorexia. +, mild; ++, moderate; +++, marked; ++++, severe.

  • b This monkey developed disseminated intravascular coagulation, which might lead to the absence of full-blown skin lesions after challenge.

  • c P values for mean lesion counts from the Dryvax-alone group were compared with those from the cidofovir+Dryvax group.

  • d P values for mean lesion counts from the cidofovir+Dryvax group were compared with those from the mock control group.