TABLE 1.

Genes differentially expressed in tumorigenic and nontumorigenic Ad12-transformed cells as determined by microarray analysis

CategoryaRatiobGenBank accession no.Gene product name
Neuronal55.7U02096Fatty acid binding protein (brain type)
24.3M63656Aldolase C (brain type)
24.3X73411snRNP-associated polypeptide N (brain type)
13.0M29293Neural snRNP
10.6X52817Neural C1-13
9.2U17604rS-Rex-b (brain type)
4.9AF041082Transmembrane receptor Robo1
4.0U08290Neuronatin alpha
3.5U09357Neural receptor-type protein tyrosine phosphatase zeta/beta
3.5AF004431Homeodomain protein Nkx6.1
3.2X06984Aldolase C (brain type)
3.2X55812SKR6, a CB1 cannabinoid receptor
−3.2AF023621Sortilin
Cell cycle10.6D14014Cyclin D1
4.6X75207Cyclin D1
Transcription6.1Y00396c-MYC oncogene and flanking regions
3.0U56242Transcription factor Maf2
−3.2L03556Hox1.3 protein (hox1.3)
−3.2X60769Silencer factor B
−6.5L23148Inhibitor of DNA binding, splice variant Id1.25
Tumor invasiveness4.0D10926Tissue factor pathway inhibitor
3.2D63886Membrane-type matrix metalloproteinase
3.2M23697Tissue-type plasminogen activator
Cell structure12.1AJ224879Collagen alpha 1 type II
−3.0AF097887Chp mRNA
−3.7X81448Keratin 18
−6.5S76054Cytokeratin-8
Immune response3.7U77777Gamma interferon-inducing factor isoform alpha precursor
−7.0U17035Mob-1
Apoptosis−3.0X96437PRG1
Miscellaneous10.8M81681Biliverdin reductase
−4.0X06483Ribosomal protein L32
−4.9L16764HSP70
−10.6Z27118HSP70
−12.1X62951mRNA (pBUS19) with repetitive elements
−21.1AJ001044EGP-314 protein homologue
ESTs/unknown9.2AI230247
9.2AI179399
9.2AI105137
8.0AA817854
6.1AA893743
5.7AA945737
4.3RX013713
4.3AA900476
4.0AA899106
3.7AI232379
3.5AA893082
3.5AA800503
3.5AA800708
3.2AI231292
3.2AA800908
3.2AAA799328
3.0AA894305
3.0AA891204
−3.0AI070295
−3.2AI177161
−3.7AA894130
−5.3RX049893
−6.1H31287
−13.9AA818604
−19.7AA892468
−21.1AI072634
−59.7AA848563
  • a Genes are categorized based on their known functions.

  • b Differential gene expression ratios between tumorigenic 12-1 and nontumorigenic 12-1sm transformed cells. A positive ratio represents higher expression in 12-1 cells, whereas a negative value denotes greater expression in 12-1sm cells.