TABLE 3.

Results of quantitative pathology and virus loads after monkeypox virus challenge

Group and animal no.Weight of organ (g)No. of lesions in lungsVirus titer (PFU/g)A33R copies/106 PBMC on day:
LungsLiverKidneysSpleenLungsSkinLymph nodes4711162128
Mock
    73379.879.916.610.5202.3 × 1092.0 × 1081.7 × 1061.3 × 1041.3 × 1042.9 × 106a
    732915.780.315.75.2303.3 × 1063.7 × 1066.7 × 1043.6 × 1041.9 × 1051.0 × 1065.6 × 106a
    732731.5128.618.69.3182.7 × 1084.3 × 1075.0 × 1057.4 × 1043.9 × 1053.0 × 106a
    732816.8106.419.07.1242.3 × 1074.0 × 1071.3 × 1052.6 × 1042.6 × 1041.7 × 106
    733417.662.911.65.78NegdNegNeg5.0 × 1031.3 × 1043.5 × 1042.0 × 103<2 × 102<2 × 102
    733617.973.613.87.86NegNegNeg1.5 × 1042.9 × 1042.5 × 1042.0 × 1032.8 × 102<2 × 102
Mean ± SD19.9 ± 5.988.6 ± 24.315.9 ± 2.87.6 ± 2.118 ± 94.1 × 1044.6 × 1044.8 × 105
Dryvax
    733213.957.08.13.90NegNegNeg<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102
    732615.087.112.64.10NegNegNeg<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102
    733013.855.19.74.90NegNegNeg<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102
    733117.474.110.83.10NegNegNeg<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102
    733319.359.911.15.10NegNegNeg<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102
    733517.562.110.14.30NegNegNeg<2 × 102<2 × 102<2 × 1023.8 × 102<2 × 102<2 × 102
Mean ± SD16.1 ± 2.265.9 ± 12.310.4 ± 1.54.3 ± 0.70<2 × 102<2 × 102<2 × 1022 × 102<2 × 102<2 × 102
Pb0.390.440.120.0040.014
Cidofovir+Dryvax
    732117.178.411.95.33NegNegNeg1.7 × 1032.9 × 103<2 × 102<2 × 102<2 × 102<2 × 102
    732514.243.89.45.44NegNegNeg8.1 × 102<2 × 102<2 × 102<2 × 102<2 × 102<2 × 102
    732018.068.213.85.32NegNegNeg4.2 × 1036.0 × 1024.5 × 103<2 × 102<2 × 102<2 × 102
    732217.184.515.45.2121.7 × 1087.3 × 1082.3 × 1063.6 × 1043.5 × 1041.2 × 1051.0 × 105a
    732313.266.910.15.6101.3 × 1042.7 × 104Neg3.2 × 1031.3 × 1051.9 × 104<2 × 102<2 × 102<2 × 102
    732414.462.711.95.42NegNegNeg2.2 × 1039.8 × 1038.1 × 103<2 × 102<2 × 102<2 × 102
Mean ± SD15.7 ± 2.067.4 ± 14.112.1 ± 2.25.4 ± 0.16 ± 53.4 × 1032.1 × 1039.7 × 102
Pc0.0440.0420.0020.0230.0150.160.1630.027
  • a Day 9 data are shown for monkeys 7337 and 7327. Day 14 data are shown for monkeys 7329 and 7322.

  • b P values for mean weights of organs, numbers of lung lesions, copies of the A33R gene, or live MPV titers in tissues of the Dryvax-alone group were compared with those of the cidofovir+Dryvax group.

  • c P values for mean weights of organs, numbers of lung lesions, copies of the A33R gene, or live MPV titers in tissues of the cidofovir+Dryvax group were compared with those of the mock control group.

  • d Neg, negative.