TABLE 1.

Development of hind-limb paralysis after intranasal infection

Intranasal virus doseDevelopment of paralysis after infection witha:
WT-VSV/GFPWT-VSV/FASTM51-VSV/FAST
5 × 1060/40/4ND
1 × 1070/51/5*ND
5 × 1070/53/5*ND
5 × 1081/5*4/4†0/5
5 × 109NDND0/5
  • a Values are expressed as the number of animals developing paralysis/total number of animals tested. *, Hind-leg paralysis appeared on day 7 postinfection; †, hind-leg paralysis appeared on day 5 in three cases and on day 7 in the fourth case. ND, not determined.