TABLE 4.

Amino acid mutations in the RNP complexes of Prague viruses possessing chimeric PA genesa

VirusPresence of PB2 mutationPresence of PA mutation
D253ND256GS279LT371IN425TH432RN540SN677TN444SA448V
Prague/Pr(Yok 1-100)PA
Prague/Pr(Yok 1-200)PA
Prague/Pr(Yok 1-300)PA
Prague/Pr(Yok 1-400)PA+
Prague/Pr(Yok 1-500)PA++
Prague/Pr(Yok 1-600)PA++
Prague/Pr(Yok 101-716)PA++
Prague/Pr(Yok 201-716)PA+
Prague/Pr(Yok 301-716)PA++
Prague/Pr(Yok 401-716)PA+
Prague/Pr(Yok 501-716)PA
Prague/Pr(Yok 601-716)PA
  • a The allantoic fluid of Prague viruses possessing chimeric PA genes was subjected to reverse transcription-PCR, and the PB2, PB1, PA, and NP genes were fully sequenced. The mutations found in the RNP complexes of the Prague chimeric PA viruses are shown. +, mutation present.