TABLE 3.

ORF annotation and filtering criteria

EBV ORFDUB scoreaEBV proteinHomologueExpression in virus cycleLocationFunctionbFilter
HSVCMVKSHV
BBRF39Glycoprotein MgMgMgMLateEnvelopeM(-)
BcLF17Major capsid proteinUL19UL86ORF25LateCapsidC-
BALF57DNA pol catalytic subunitUL30UL54ORF9EarlyNucleusR
BGRF1/BDRF17DNA packaging, TerminaseUL15UL89ORF29LateNucleusP
BNRF16Major tegument proteinORF75LateTegumentT
BPLF16Large tegument proteinUL36UL48ORF64LateTegumentT
BXLF25gp85, gH homologueUL22UL75ORF22LateEnvelopeM(-)
ORF355Hypothetical
ORF885Hypothetical-
BALF25ssDNA binding proteinUL29UL57ORF6EarlyNucleusR
BSLF15Helicase/primase complexUL52UL70ORF56EarlyNucleusR
BILF14gp64, constitutive GPCREarlyMembraneM(-)
BERF3-BERF44EBNA3CLatentNucleusL
BaRF14RNase reductaseUL40ORF60EarlyNucleusN
BRLF14Rta, transactivatorORF50I-EarlyNucleusS
BXLF14Thymidine kinaseUL23ORF21EarlyNucleusN
  • a For the details on the scoring, see Table S4 in the supplemental material.

  • b Classification of protein based on function: C, capsid; M, membrane protein; N, nucleotide metabolism; L, latency; P, packaging; R, replication; S, signaling, transactivator, transcription factor; T, tegument.