TABLE 4.

Amino acid sequence comparisons of HCV HLA-A2 epitopes sequences with counterparts derived from genotype 1b, 1a, and 4 isolates

ProteinEpitope% Conservation genotypea
1b1a4
CC35-4495 (195/206)100 (56/56)100 (11/11)
C132-14096 (197/206)97 (58/60)78 (8/11)
E1E1 220-22778 (178/229)0 (0/397)0 (0/15)
E1 257-26683 (191/229)0 (0/397)0 (0/15)
E1 363-37284 (189/224)91 (365/401)0 (0/10)
E2E2 401-4110 (0/143)0 (0/391)0 (0/11)
E2 614-62280 (115/143)88 (15/17)0 (0/1)
E2 686-69498 (138/141)94 (15/16)100 (1/1)
E2 725-73490 (127/141)94 (15/16)100 (1/1)
NS3NS3 1073-108162 (84/136)0 (0/14)0 (0/1)
NS3 1169-117728 (38/136)0 (0/14)0 (0/1)
NS3 1406-141515 (20/135)0 (0/14)0 (0/1)
NS3 1585-159396 (130/135)100 (14/14)100 (1/1)
NS4NS4B 1769-17770 (0/30)0 (0/14)0 (0/2)
NS4B 1789-179793 (28/30)100 (14/14)0 (0/2)
NS4B 1807-181697 (29/30)100 (14/14)100 (1/1)
NS4B 1851-185993 (28/30)100 (14/14)0 (0/1)
NS5ANS5A 2221-223183 (115/139)0 (0/14)0 (0/1)
NS5A 2252-226040 (56/139)0 (0/14)0 (0/1)
NS5BNS5B 2578-258796 (136/142)100 (14/14)0 (0/1)
NS5B 2594-260299 (141/142)0 (0/14)0 (0/1)
NS5B 2727-273587 (123/142)0 (0/14)0 (0/1)
  • a That is the number of isolates presenting a homology of 100% with the epitope sequences used in our study (derived from the HCV-JA isolate)/the total number of isolate sequences aligned.