TABLE 1.

Summary of HCV epitopes targeted by the CD4+ T-helper-cell response

PeptideAmino acidsHCV proteinSubject no.Sequence
p221-40Core1DVKFPGGGQIVGGVYLLPRR
p991-110Core1CGWAGWLLSPRGSRPSWGPT
p14141-160Core1GAPLGGAARALAHGVRVLED
p1001001-1020NS22PVSARRGREILLGPADGMVS
p1131131-1150NS33YLVTRHADVIPVRRRGDSRG
p1201201-1220NS31LETTMRSPVFTDNSSPPVVP
p1241241-1260NS31, 2PAAYAAQGYKVLVLNPSVAA
p1281281-1300NS33GVRTITTGSPITYSTYGKFL
p1291291-1310NS32ITYSTYGKFLADGGCSGGAY
p1321321-1340NS33TDATSILGIGTVLDQAETAG
p1411411-1430NS32GINAVAYYRGLDVSVIPTSG
p1521521-1540NS32YDAGCAWYELTPAETTVRLR
p1531531-1550NS33TPAETTVRLRAYMNTPGLPV
p1581581-1600NS32, 3ENLPYLVAYQATVCARAQAP
p1601601-1620NS33PPSWDQMWKCLIRLKPTLHG
p1621621-1640NS32PTPLLYRLGAVQNEITLTHP
p167a1671-1690NS41AAYCLSTGCVVIVGRVVLSG
p1771771-1790NS41, 3GIQYLAGLSTLPGNPAIASL
p1781781-1800NS42LPGNPAIASLMAFTAAVTSP
p1801801-1820NS42LTTSQTLLFNILGGWVAAQL
p1871871-1890NS42GEVPSTEDLVNLLPAILSPG
p189a1891-1910NS41ALVVGVVCAAILRRHVGPGE
p1911911-1930NS41, 2GAVQWMNRLIAFASRGNHVS
p2272271-2290NS51PAEILRKSRRFAQALPVWAR
p2452451-2470NS53LRHHNLVYSTTSRSACQRQK
p2472471-2490NS52KVTFDRLQVLDSHYQDVLKE
p2542541-2560NS53SVWKDLLEDNVTPIDTTIMA
p2572571-2590NS53KGGRKPARLIVFPDLGVRVC
p2602601-2620NS53KLPLAVMGSSYGFQYSPGQR
p2622621-2640NS53VEFLVQAWKSKKTPMGFSYD
p2652651-2670NS53SDIRTEEAIYQCCDLDPQAR
p2662661-2680NS52QCCDLDPQARVAIKSLTERL
p2792791-2810NS51SVAHDGAGKRVYYLTRDPTT
p2832831-2850NS53NIIMFAPTLWARMILMTHFF
p284a2841-2860NS51ARMILMTHFFSVLIARDQLE
p2902901-2920NS51EINRVAACLRKLGVPPLRAW
p2942941-2930NS51CGKYLFNWAVRTKLKLTPIA
  • a This peptide was not identified in the bulk expanded populations but required limiting dilution cloning.