TABLE 2.

Summary of effects of nectin-1 and nectin-2 mutations

ProteinViral entryNectin-nectin interactions
HSV-1HSV-1 Rid1HSV-2PRVBHV-1HomotypicHeterotypic with nectin-3
Nectin-1
    Wild type+a++++++
    QN76-    77AA;     M85F++++
    R110P
    F129L++++
Nectin-2
    Wild typeNAb+++NA+NDc
    M89FNA+NA+ND
    A126PNANAND
    F145LNANAND
  • a A plus sign indicates that activity is equivalent to that observed for wild-type nectin-1 or nectin-2. One or two downward arrows denote somewhat or drastically reduced levels of activity, respectively.

  • b NA, wild-type nectin-2 is not able to mediate entry of some of the viruses used.

  • c ND, not determined.