TABLE 1.

Amino acid differences between YFV 17D-204 and Asibi strains

E residueaAmino acid at indicated E residue in strainLocalizationPresence in all 17D substrainsd
Asibi17D-204
52bGlyArgcdII+
56AlaValdII
170AlaValdI+
173bThrIlecdI+
200bLysThrcdII+
299MetIledIII+
305bSerPhecdIII+
325bProSercdIII
331LysArgdIII+
380bThrArgcdIII+
407AlaValStem-anchor+
416AlaThrcStem-anchor
  • a Residue numbering is from the amino terminus of E.

  • b Changes analyzed in this study.

  • c Nonconservative change.

  • d Changes common to 17D-204, 17D-213, and 17DD substrains are indicated by a +, while those absent from one or more or the three are indicated by a −.