TABLE 1.

VZV infection of naive and memory CD4+ T cellsa

Expt% of cells infected with VZV in CD4+ subset:Memory/naive ratio
NaiveMemory
15.922.63.8
25.713.42.4
35.015.03.0
414.040.72.9
54.014.03.5
    Mean ± SE6.9 ± 1.821.0 ± 5.23.1 ± 0.25b
  • a Column-purified tonsillar T cells were stained with anti-CD4 and anti-CD45RA MAbs and separated into CD4+ CD45RA+ naive and CD4+ CD45RA memory T cells by cell sorting. The subpopulations were added to a monolayer of V-Oka-infected HEL cells and harvested at 2 days postinfection. The percentages of cells that had been infected with VZV were determined as described in the legend to Fig. 1. In five independent experiments, the mean percentage of memory CD4+ T cells that were VZV infected was threefold higher than that of naive CD4+ T cells.

  • b P < 0.05 by paired t test.