TABLE 1.

Characteristic of the rAAV doses injected and Epo regulation outputs

AnimalarAAVDoseb (i.p./kg)Peak value of Epoc (mIU/ml)No. of rEpod peaksDetection of anti-rtTA antibodies
Mac 3cmET (LTR)2.5 × 109NDeND
Mac 4cmET (LTR)8.0 × 109124+
Mac 5cmET (CAG)3.0 × 109132+
Mac 6cmET (CAG)1.0 × 1010652+
Mac 7cmET (CAG)4.0 × 109135+
Mac 8cmET (CAG)4.0 × 10917PersistingND
  • a See reference 8.

  • b i.p., infectious particles.

  • c First induction.

  • d rEpo, recombinant Epo.

  • e ND, not detectable.