TABLE 1.

Viral infection following preincubation of cells or virus for 1 h with SAMMA or control media

SAMMA concin (μg/ml)Viral activity after following treatmenta
Pretreated cells (no wash)Pretreated cells (wash)Pretreated virus (no dilution)Pretreated virus (50-fold dilution) (Final [SAMMA] after dilution)
HIV-1IIIB on U87 CD4+ CXCR4+ cells
    199 ± 19113 ± 7*11 ± 1186 ± 13 (0.02)
    10*48 ± 899 ± 9*0*44 ± 5 (0.2)
    100*11 ± 1.491 ± 10*0*3 ± 2 (2)
HSV-2(G) on CaSki cells
    195 ± 1.471 ± 1.444 ± 31128 ± 2 (0.02)
    10*5 ± 078 ± 8.5*0*60 ± 6 (0.2)
    100*071 ± 1.4*0*0 (2)
  • a Results are presented as p24 (HIV) or PFU formed (HSV) in the presence of SAMMA as a percentage of p24 or PFU in the absence of drug and are the mean ± standard deviation of at least two independent experiments conducted in triplicate (HIV) or duplicate (HSV). For each experimental condition, the effects of SAMMA were compared to those of control medium by using the Student unpaired t test. Asterisks indicate a significant reduction in viral infection (P ≤ 0.001).