TABLE 1.

Summary of HPV16 E6 mutant characterizationa

HPV16 geneE6AP bindingP53 (37°C) degradationP53 in early passage MECsbStable replication
Wild type++++++LowYes
F2L+++++NDcYes
F2V+++NormalNo
Y54H+++NormalNo
C63R+++NormalYes
L110QNormalNo
Δ118-122++/−LowNo
8S9A10T+NormalNo
  • a The first three columns refer to previously published data for in vitro binding between E6 and E6AP, in vitro degradation of P53 by E6, and level of p53 proteins in mammary epithelial cells expressing wild-type or mutant HPV16 E6, respectively (17, 20, 33). The fourth column summarizes the results from replication assays in this report.

  • b MECs, human mammary epithelial cells.

  • c ND, not done.