TABLE 2.

Blocking by antibodies of apical measles virus infection of polarized epithelial cellsa

MAb (400 μg/ml)Apical supernatantCell lysate
Virus titer (10−2 PFU/ml)% Reduction of virusbVirus titer (10−4 PFU/ml)% Reduction of virusb
Anti-H IgA0c1000.68 ± 0.07c82
Anti-H IgG4.55 ± 0.70c413.20 ± 0.42d15
Anti-F IgA5.00 ± 0.28c352.78 ± 0.81d26
Anti-F IgG4.40 ± 0.57c433.20 ± 0.28d15
Anti-N IgA5.75 ± 0.35c263.55 ± 0.35d6
Anti-N IgG6.90 ± 0.57d113.57 ± 0.11d6
Irrelevant IgA8.10 ± 0.0704.40 ± 0.140
None7.75 ± 0.3503.78 ± 0.600
  • a Experiments were repeated on at least three occasions with similar results. Results of a representative experiment are shown. Data are means ± standard deviations (n = 3).

  • b Compared to no-antibody control.

  • c Mean virus titers were significantly lower (P ≤ 0.002) than those from cells exposed to no antibody.

  • d Mean virus titers were not significantly lower (P ≥ 0.05) than those from cells exposed to no antibody.