TABLE 1.

Replication of recombinant RSV in mice and cotton rats

VirusVirus titer in lungs (mean log10 PFU/g ± SE)a
MiceCotton rats
rA24.64 ± 0.084.72 ± 0.08
rA2-PP22.80 ± 0.292.91 ± 0.29
rA2-PP51.58 ± 1.061.61 ± 0.80
  • a Groups of eight Balb/c mice or cotton rats were inoculated with 106 PFU of virus intranasally under light anesthesia on day 0 and sacrificed on day 4. Virus titers per gram of lung tissue were determined by plaque assay.