TABLE 1.

Lung inflammatory mediators following primary and secondary infections

MediatoraLevel (ng/ml) on day 9 after primary infectionSignificanceeLevel (ng/ml) on day 7 after secondary infectionSignificance
Adult micebNeonatal micecAdult micedNeonatal miced
Mean±SEMMean±SEMMean±SEMMean±SEM
IL-40.660.220.260.12NS0.080.020.580.41NS
IL-54.051.1310.915.14NS1.280.239.396.24NS
IL-965.3633.0244.7312.6***5.760.0027.154.57NS
IL-1529.5324.955.8732.9NS0.400.240.990.00NS
CCL5232.48.155.601.57***9.811.6820.906.16NS
TNF11.942.161.210.15NS5.172.303.220.51NS
  • a Inflammatory mediators were measured in BAL fluid. Shown are means from experiments using three or more mice.

  • b Primary infection occurred at 4 weeks of age.

  • c Primary infection occurred at 4 days of age.

  • d Secondary infection occurred 8 weeks after the primary infection.

  • e NS, not significant; ***, P < 0.001.