TABLE 1.

Genes upregulated more than 10-fold in all of the HTLV-1-carrying T-cell lines compared with the HTLV-1-negative T-cell line MOLT-4a

Accession no.SymbolRelative expression level (fold change)Gene product
S1TMT-2M8166
NM_138410CKLFSF71,886.6 ± 188.7293.0 ± 31.0113.3 ± 19.9CKLF-like MARVEL transmembrane domain containing 7 isoform a
NM_001252CD701,375.3 ± 137.52,635.3 ± 263.52,594.8 ± 259.5Tumor necrosis factor ligand superfamily, member 7
NM_005572FPL769.8 ± 88.2822.0 ± 155.11,361.6 ± 136.2Lamin A/C isoform 2
NM_004364CEBP539.9 ± 191.387.2 ± 8.756.9 ± 19.8CCAAT/enhancer binding protein α
NM_022555HLA-DR3B474.0 ± 93.814.4 ± 4.954.0 ± 45.3MHC II, DRβ3 precursor
NM_004364CEBP468.8 ± 144.772.8 ± 7.347.1 ± 17.4CCAAT/enhancer binding protein alpha
NM_002304NM_002304336.0 ± 78.3172.3 ± 36.6135.3 ± 16.4
NM_002166GIG8331.2 ± 33.1265.4 ± 31.047.3 ± 24.0Inhibitor of DNA binding 2
NM_024644FLJ21802325.1 ± 32.5108.8 ± 18.0107.3 ± 35.1Chromosome 14 open reading frame 169
NM_015392CAB275.4 ± 27.5130.9 ± 13.123.4 ± 2.3Neural proliferation 1, differentiation and control
NM_014580GLUT8221.3 ± 22.193.3 ± 13.0116.4 ± 11.8Solute carrier family 2, (facilitated glucose transporter) member 8
NM_024710TMEM101217.8 ± 37.6228.6 ± 54.0245.8 ± 66.3Isochorismatase domain containing 2
NM_015691BM042204.4 ± 20.480.5 ± 8.034.5 ± 7.7WWC family member 3
NM_015892GALNAC4S-6ST178.9 ± 18.240.5 ± 6.837.0 ± 3.8B-cell RAG-associated protein
NM_001017535NR1I1140.8 ± 42.1178.1 ± 81.8109.3 ± 66.6Vitamin D (1,25-dihydroxyvitamin D3) receptor
NM_033518SN2113.5 ± 26.631.5 ± 11.658.5 ± 22.2Amino acid transport system N2
NM_181078NILR112.5 ± 11.3127.1 ± 25.3178.5 ± 17.8IL-21 receptor precursor
NM_012081ELL2112.4 ± 23.252.9 ± 5.319.7 ± 2.0Elongation factor 2, RNA polymerase II
ENST00000297871102.3 ± 10.282.4 ± 8.295.9 ± 9.6
NM_004737MDC1D97.8 ± 15.415.8 ± 1.7106.7 ± 26.4Like glycosyltransferase
NM_139346AMPH283.6 ± 8.4129.0 ± 12.9119.6 ± 12.6Bridging integrator 1 isoform 8
NM_022121THW74.0 ± 7.429.3 ± 3.065.1 ± 6.6PERP, TP53 apoptosis effector
NM_014580GLUT871.7 ± 7.226.0 ± 3.131.0 ± 3.1Solute carrier family 2, (facilitated glucose transporter) member 8
NM_004350AML267.8 ± 6.824.9 ± 2.561.0 ± 6.1Runt-related transcription factor 3 isoform 1
NM_012465KIAA093265.1 ± 13.324.5 ± 7.720.2 ± 2.7Tolloid-like 2
NM_000447AD464.6 ± 9.487.4 ± 19.158.6 ± 8.1Presenilin 2 isoform 1
NM_016010CGI-6263.1 ± 6.324.6 ± 2.523.5 ± 2.4Hypothetical protein LOC51101
NM_000447AD462.2 ± 12.090.9 ± 19.757.1 ± 11.1Presenilin 2 isoform 1
NM_000786LDM60.9 ± 8.159.2 ± 11.663.0 ± 6.3Cytochrome P450, family 51
NM_005658EBI654.6 ± 35.485.3 ± 14.2165.7 ± 71.1TNF receptor-associated factor 1
NM_025195C8FW53.8 ± 19.9170.5 ± 17.129.9 ± 3.7G-protein-coupled receptor-induced protein
NM_002306GAL352.1 ± 5.2133.4 ± 14.681.8 ± 11.0Galectin 3
AK057088AK05708851.8 ± 5.211.4 ± 1.120.4 ± 2.0
NM_000786LDM50.9 ± 7.149.2 ± 11.552.6 ± 5.3Cytochrome P450, family 51
NM_000958EP450.3 ± 10.522.7 ± 4.643.0 ± 7.0Prostaglandin E receptor 4, subtype EP4
NM_177925MGC92148.9 ± 4.9134.3 ± 13.4132.5 ± 13.3H2A histone family, member J isoform 1
NM_003254EPA48.0 ± 15.720.1 ± 2.710.9 ± 3.2Tissue inhibitor of metalloproteinase 1 precursor
NM_018094GST247.4 ± 5.068.6 ± 6.968.1 ± 7.2Peptide chain release factor 3
BC018597TEX26443.8 ± 4.451.8 ± 5.274.4 ± 10.0
THC244022943.7 ± 9.913.5 ± 4.211.3 ± 3.1
NM_002200IRF543.7 ± 5.3229.9 ± 23.048.9 ± 7.3Interferon regulatory factor 5 isoform a
NM_014178amisyn38.5 ± 3.9200.4 ± 32.530.6 ± 3.1Amisyn
NM_014417JFY138.4 ± 9.482.8 ± 14.8118.3 ± 49.0BCL2 binding component 3
NM_000199HSS37.6 ± 4.710.5 ± 1.012.8 ± 1.4N-Sulfoglucosamine sulfohydrolase (sulfamidase)
AK090416RXRA37.3 ± 8.112.3 ± 4.127.9 ± 10.2FLJ00318 protein
NM_000418CD12437.2 ± 6.243.8 ± 4.429.6 ± 9.7Interleukin 4 receptor α chain isoform a precursor
NM_015111N4BP336.5 ± 5.514.2 ± 1.427.5 ± 2.9Nedd4 binding protein 3
NM_015459DKFZP564J086334.8 ± 6.626.2 ± 2.618.5 ± 5.4Hypothetical protein LOC25923
NM_018664SNFT34.7 ± 3.524.6 ± 2.511.7 ± 2.5Jun dimerization protein p21SNFT
NM_013385CYT434.1 ± 3.416.2 ± 4.7107.6 ± 34.4Pleckstrin homology, Sec7, and coiled-coil
NR_002323TUG133.4 ± 3.330.3 ± 3.030.1 ± 5.2    domains 4
BC004219MGC460433.1 ± 3.321.0 ± 2.113.0 ± 3.21-Acylglycerol-3-phosphate O-acyltransferase 3
BC035647HLA-B33.0 ± 6.352.4 ± 5.236.3 ± 5.7
NM_006035MRCKB32.0 ± 3.265.7 ± 6.674.0 ± 7.4CDC42-binding protein kinase β
NM_001919CD79A31.8 ± 3.215.6 ± 1.727.2 ± 4.0Dodecenoyl-coenzyme A δ isomerase precursor
BQ189193ICOSLG31.8 ± 14.230.1 ± 3.872.7 ± 7.3
THC240108731.2 ± 3.142.5 ± 4.214.6 ± 4.0
NM_001852MED30.7 ± 6.6172.2 ± 33.352.9 ± 5.3α2 type IX collagen
NM_004357GP2730.0 ± 4.434.0 ± 3.414.5 ± 4.5CD151 antigen
NM_006509I-REL29.9 ± 3.065.0 ± 6.543.5 ± 5.1Reticuloendotheliosis viral oncogene homolog B
AK096677AK09667729.2 ± 3.829.7 ± 7.273.3 ± 36.4
NM_024758FLJ2338427.7 ± 4.523.1 ± 5.613.6 ± 2.1Agmatine ureohydrolase (agmatinase)
AK021777FLJ0020525.8 ± 2.616.8 ± 1.719.9 ± 2.0GalNAc transferase 10 isoform b
NM_001953TP25.2 ± 2.543.2 ± 4.330.8 ± 5.9Endothelial cell growth factor 1 (platelet-derived)
NM_020731AHH24.8 ± 5.310.1 ± 1.699.4 ± 42.5Arylhydrocarbon receptor repressor
NM_002413GST224.6 ± 5.645.4 ± 4.651.5 ± 5.2Microsomal glutathione S-transferase 2
NM_014383Rog24.3 ± 2.441.1 ± 4.112.5 ± 3.8Testis zinc finger protein
NM_003928MGC11741124.2 ± 2.461.8 ± 7.135.8 ± 3.6CAAX box 1
BX362492BX36249223.1 ± 4.026.3 ± 2.842.5 ± 11.0
NM_033375myr220.8 ± 2.945.4 ± 8.248.5 ± 8.3Myosin IC
NM_213589LPD20.6 ± 2.314.9 ± 3.524.8 ± 3.1Ras association and pleckstrin homology domains 1 isoform 2
NM_004838HOMER-320.3 ± 2.0193.6 ± 23.684.5 ± 15.8Homer 3, neuronal immediate early gene
A_23_P37070718.2 ± 7.742.1 ± 4.230.1 ± 7.0
AB033060AHH17.9 ± 3.912.2 ± 1.2114.8 ± 22.4Arylhydrocarbon receptor repressor
BC024020VMP117.6 ± 2.639.6 ± 4.022.8 ± 6.0Transmembrane protein 49
NM_023076FLJ2336017.6 ± 3.121.2 ± 4.020.5 ± 2.8Hypothetical protein LOC65259
AK097976DLEU217.2 ± 3.122.5 ± 5.313.6 ± 8.3
NM_003842DR516.7 ± 1.732.9 ± 4.037.2 ± 3.7TNF receptor superfamily, member 10b isoform 1 precursor
NM_024646ZYG1116.5 ± 1.711.1 ± 1.115.1 ± 1.5Zyg-11 homolog B
AK092921HLA-B16.3 ± 1.625.7 ± 2.619.9 ± 2.0
NM_022152RECS116.2 ± 1.613.6 ± 2.914.7 ± 3.0Transmembrane BAX inhibitor motif containing 1
AA451906BIN115.4 ± 1.518.2 ± 2.017.3 ± 1.7
NM_018370DRAM15.3 ± 2.580.9 ± 14.741.6 ± 10.8Damage-regulated autophagy modulator
NM_005514HLA B15.2 ± 1.732.3 ± 3.228.0 ± 4.9MHC I, B
THC240364414.9 ± 4.417.5 ± 5.915.0 ± 5.0
NM_000152LYAG14.7 ± 1.515.8 ± 2.413.0 ± 2.1Acid α-glucosidase preproprotein
ENST0000035580414.4 ± 1.423.7 ± 2.813.1 ± 1.7
NM_001613ACTSA14.4 ± 1.635.3 ± 5.422.3 ± 2.3α2 actin
NM_018370DRAM14.3 ± 2.373.3 ± 12.433.9 ± 7.7Damage-regulated autophagy modulator
A_24_P10177114.0 ± 1.521.3 ± 2.219.3 ± 3.3
NM_017789SEMAI13.9 ± 1.720.4 ± 2.533.9 ± 13.8Semaphorin 4C
NM_002502LYT1013.3 ± 4.315.4 ± 1.045.9 ± 2.8Nuclear factor of κ light polypeptide gene enhancer in B cells 2 (p49/p100)
NM_031419IKBZ12.6 ± 4.637.1 ± 4.9134.0 ± 62.5Nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor, ζ isoform b
NM_015516TSK12.5 ± 1.212.7 ± 1.312.2 ± 1.2Tsukushi
CR594843HLA-B12.2 ± 1.211.5 ± 1.210.1 ± 1.9
NM_018950HLAF12.1 ± 1.816.7 ± 1.713.7 ± 2.0MHC I, F precursor
NM_024567PBHNF12.0 ± 1.915.3 ± 3.017.0 ± 2.8Homeobox containing 1
NM_003764FHL412.0 ± 2.114.0 ± 1.411.7 ± 4.4Syntaxin 11
THC227654711.9 ± 1.316.8 ± 4.730.9 ± 9.6
CA431756CTTN11.3 ± 1.413.8 ± 1.512.8 ± 3.1
CR608347HLA-B11.0 ± 1.216.5 ± 1.412.7 ± 1.9
NM_005261KIR11.0 ± 4.596.2 ± 9.697.3 ± 56.7GTP-binding mitogen-induced T-cell protein
NM_130446FLJ0002911.0 ± 1.211.6 ± 3.513.6 ± 7.1Kelch-like 6
NM_017789SEMAI10.9 ± 1.116.4 ± 1.624.6 ± 10.4Semaphorin 4C
BC037255LOC38963410.6 ± 1.116.8 ± 3.021.3 ± 6.4Hypothetical protein LOC389634
AF009619CASH10.6 ± 1.716.4 ± 3.385.1 ± 38.2CASP8 and FADD-like apoptosis regulator
NM_006674P5-110.5 ± 1.258.0 ± 5.891.4 ± 9.3HLA complex P5
NR_001434HLAHP10.2 ± 1.015.7 ± 1.618.5 ± 2.4
  • a The genes of which expression levels were more than 10-fold in all of the three HTLV-1-carrying T-cell lines (S1T, MT-2, and M8166) compared with the control T-cell line (MOLT-4) with statistical significance (P < 0.05) are listed and sorted by the expression level in S1T cells. All data represent means ± standard deviations for three independent microarray experiments.