TABLE 1.

Optimal CTL epitopes in AC-06

Binding motif and HIV-1 proteinOptimal epitopeaHLA restrictionDesignation
A3 binding motif2C terminus
LK
VY
MF
    p17 GagKIRLRPGGKA3A3-KK9
    p17 GagRLRPGGKKKA3A3-RK9
    RT PolKLVDFRELNKA3A3-KK10
    RT PolGIPHPAGLKA3A3-GK9
    RT PolAIFQSSMTKA3A3-ATK9
    RT PolQIYPGIKVRA3A3-QR9
    RT PolRMRGAHTNDVKA3A3-RK11
    Int PolAVFIHNFKRKA3A3-AK10
    gp 41 EnvRLRDLLLIVTRA3A3-RR11
    NefQVPLRPMTYKA3A3-QK10
    NefAVDLSHFLKA3A3-ALK9
    RevERILSTYLGRA3A3-ER10
    VifRIRTWKSLVKA3A3-RK10
    VifHMYISKKAKA3A3-HK9
    VifKTKPPLPSVKKA3A3-KK11
B7 binding motif123C terminus
PL
AR
RK
    p24 GagSPRTLNAWVB7B7-SV9
    p24 GagTPQDLNTMLB7B7-TL9
    p24 GagHPVHAGPIAB7B7-HA9
    p24 GagGPGHKARVLB7B7-GL9
    RT PolSPAIFQSSMB7B7-SM9
    gp120 EnvRPNNNTRKSIB7B7-RI10
    gp41 EnvIPRRIRQGLB7B7-IL9
    NefTPQVPLRPMB7B7-TM9
    NefRPMTYKAALB7B7-RL9
    VprFPRIWLHGLB7B7-FL9
    VifHPRVSSEVHIB7B7-HI10
Cw7 binding motif23456C terminus
YPDVVY
PGEYIF
RAVIL
    NefRRQDILDLWIYCw7Cw7-RY11
  • a Novel epitopes are boldfaced. Based on the described epitope binding motif for each HLA class I allele (13, 33), the amino acids preferentially located at the corresponding positions of the epitopes are shown.