TABLE 7.

Alternative analyses showing consistent and inconsistent HLA associations with HIV-1 RNA levels in seropositive Zambians, stratified by sex

Patient characteristicSeropositive females (n = 137)Seropositive males (n = 122)
Marker positive (no. of patients)Marker negative (no. of patients)Adjusted P valueaMarker positive (no. of patients)Marker negative (no. of patients)Adjusted P valuea
Consistent HLA markers
    A*02-Cw*16 (n = 15)4.95 ± 4.48 (9)4.48 ± 0.75 (128)0.0535.06 ± 0.55 (6)4.84 ± 0.78 (116)0.255
    A*23-B*14 (n = 12)4.91 ± 0.65 (6)4.49 ± 0.77 (131)0.0765.38 ± 0.51 (6)4.83 ± 0.77 (116)0.056
    A*23-Cw*07 (n = 18)4.76 ± 0.44 (7)4.50 ± 0.78 (130)0.5205.33 ± 0.49 (11)4.81 ± 0.77 (111)0.076
    A*30-Cw*03 (n = 12)3.86 ± 0.90 (6)4.54 ± 0.75 (131)0.0504.42 ± 0.44 (6)4.88 ± 0.77 (116)0.175
    B*39 (n = 9)3.87 ± 1.15 (6)4.54 ± 0.74 (131)0.0633.93 ± 0.59 (3)4.88 ± 0.76 (119)0.076
    B*57 (n = 18)4.00 ± 0.90 (10)4.55 ± 0.74 (127)0.0114.25 ± 0.71 (8)4.90 ± 0.76 (114)0.008
Other markers of interestb
    B*35 (n = 15)4.49 ± 0.86 (10)4.51 ± 0.76 (127)0.9435.15 ± 0.81 (5)4.84 ± 0.77 (117)0.784
    B*53 (n = 53)4.70 ± 0.63 (31)4.46 ± 0.80 (106)0.0764.74 ± 0.98 (22)4.88 ± 0.71 (100)0.580
  • a Based on univariate general linear model analyses adjusted for age and patient group membership, with the latter reflecting duration of infection and viral transmissibility. Additional summarizing statistics are shown in Tables 4 and 5.

  • b Based on analyses of data from other cohort studies.