TABLE 5.

HLA variants associated with HIV-1 RNA level as a continuous variable

HLA variant or variant statusNo. of carriersLog10 VL (mean ± SD)Unadjusted GLM P valueAdjusteda GLM P value
A*02-Cw*16154.997 ± 0.7690.0100.025
    A*02-Cw*16-B*45114.951 ± 0.8700.2300.081
A*23-B*14125.143 ± 0.6080.0330.009
    A*23-Cw*08125.070 ± 0.5760.0720.030
        A*23-Cw*08-B*14105.053 ± 0.6210.1180.078
    A*23-Cw*07185.106 ± 0.5400.0150.075
A*29-B*42114.398 ± 0.7040.2340.094
A*30-B*57114.089 ± 0.6030.0110.004
    A*30-Cw*18-B*5794.196 ± 0.5950.0620.025
    A*30-Cw*03124.143 ± 0.7380.0160.017
        A*30-Cw*03-B*1584.105 ± 0.7100.0360.018
A*3601414.881 ± 0.6770.0650.042
A*68744.836 ± 0.7270.0340.022
A*74-B*15124.298 ± 0.8770.0880.076
B*13104.038 ± 1.0260.0090.019
B*18144.986 ± 0.4360.1250.069
B*3993.891 ± 0.9600.0020.010
    B*39-Cw*1283.995 ± 0.8380.0120.039
B*4175.052 ± 0.5520.1960.166
B*45444.885 ± 0.6490.0500.061
    B*45-Cw*16264.957 ± 0.6310.0510.067
B*57184.111 ± 0.8070.0020.0002
    B*57-Cw*18154.090 ± 0.7820.0030.0006
Cw*1283.995 ± 0.9700.0120.039
Cw*16414.867 ± 0.6100.0850.059
Cw*18324.276 ± 0.7960.0020.0006
    Cw*18, no B*57174.415 ± 0.7940.2050.205
Consistently favorableb374.110 ± 0.799<0.0001<0.0001
Unfavorableb435.052 ± 0.6250.00050.0002
  • a Adjusted for age, sex, and patient group membership (TPDs, transmission pair SCs, and discordant pair seropositives).

  • b Favorable (A*30-Cw*03, B*39, and B*57) and unfavorable (A*02-Cw*16, A*23-B*14, and A*23-Cw*07) HLA variants show consistent associations with viral RNA levels in both categorical and general linear model statistics (Tables 4 to 5) as well as in alternative analyses based on sex group membership (Table 7).