TABLE 4.

HLA variants with apparent associations with HIV-1 RNA level as a categorical variable

HLA variant or variant statusdTotal no. of subjectsNo. of subjects with a plasma HIV-1 RNA level (copies per ml) of:P value
<10,000 (n = 55)10,000-100,000 (n = 106)>100,000 (n = 98)UnadjustedAdjusteda
A*02-Cw*16151590.0510.008
    A*02-B*45-Cw*16111460.1930.040
A*23-B*14121470.1150.031
    A*23-Cw*08b121560.2370.106
        A*23-Cw*08-B*14b101450.3160.192
    A*23-Cw*071816110.0230.084
A*29-B*42113710.1170.019
A*30-B*57115600.0050.001
    A*30-Cw*18-B*5793600.0430.011
    A*30-Cw*03125610.0180.008
        A*30-Cw*03-B*1584310.0390.012
A*3601b41420170.1610.163
A*68741228340.0760.087
A*74-B*15b124620.1160.142
B*13104420.1160.129
B*18140770.0880.060
B*3996210.0030.012
    B*39-Cw*1285210.0110.025
B*4170250.0500.019
B*4544319220.0100.011
    B*45-Cw*1626111140.0170.020
B*57188910.0010.001
    B*57-Cw*18156900.0030.002
Cw*1285210.0110.025
Cw*1641417200.0370.037
Cw*1832141350.00030.0003
    Cw*18, no B*57178450.0520.067
Consistently favorablec3717173<0.0001<0.0001
Unfavorablec43315250.0040.0005
  • a Adjusted for age, sex, and patient group membership (TPDs, transmission pair SCs, and discordant pair seropositives).

  • b Became marginally significant in subsequent analyses (Table 5).

  • c Favorable (A*30-Cw*03, B*39, and B*57) and unfavorable (A*02-Cw*16, A*23-B*14, and A*23-Cw*07) HLA variants show consistent associations with viral RNA levels in both categorical and general linear model statistics (Tables 4 and 5) as well as in alternative analyses based on sex or group membership (Table 7).

  • d Indented entry(s) represents subset(s) of preceding entry.